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On the other hand, breath-powered bidirectional sprayers are engineered to address the nasal valve as a primary deposition barrier by utilising patient-generated exhalation to establish positive intranasal pressure and facilitate a “through-the-nose” airflow pathway (Djupesland et al., 2006)

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doi: 10.1073/pnas.93.20.10595 26 MaxwellPHWiesenerMSChangGWCliffordSCVauxECCockmanMEet al